Vasculitis (Wegeners Granulmatosis)
Vasculitis is a type of inflammation (redness, heat and swelling) of blood vessels. Vasculitis is an autoimmune disorder where the immune system attacks its own blood vessels causing inflammation. This results in narrowing or closing of the blood vessels. It may sometimes lead to stretching and bulging of the blood vessels (aneurysm) which may burst and bleed and can lead to death. Vasculitis can occur at any age and causes serious complications depending on which organ systems are involved.
Depending on the part of the body that is affected, symptoms will vary. The areas affected with vasculitis are listed below with their respective symptoms:
Skin – various kinds of spots and bruises
Joints – Arthritis
Lungs – shortness of breath and sometimes blood with coughing (haemoptysis)
Gastrointestinal tract – mouth sores, stomach pain and intestinal wall bleeding; in severe cases it can be fatal
Nose and ear – sinus or nose ulcers and middle ear infection or hearing loss in some cases
Eyes – redness, blurred vision, sensitivity to light and even blindness in rare cases
Brain – headache, stroke-like symptoms and even paralysis in severe cases
Nerves – Numbness in different parts of the body and sharp severe pain in the hands and legs
Other general symptoms can include fever, weight loss, aches and pain. The condition may suddenly go in remission or flare up in certain cases.
Vasculitis is mostly linked to other auto-immune disorders and may occur in patients suffering already with lupus, scleroderma or rheumatoid arthritis. It may also co-occur with leukaemia and lymphoma. Smoking and hepatitis B and C infection also increases the risk for developing vasculitis.
Diagnosis is done by the doctor based on the medical history, physical examination, symptoms and result of various diagnostic tests. Tests that the doctor orders to confirm vasculitis may include:
Blood test for Erythrocyte sedimentation rate, C-reactive protein, haemoglobin and haematocrit and antineutrophil cytoplasmic antibodies
Biopsy of the affected blood vessel or organization
Lung function test
Angiography of affected blood vessels
There is no guaranteed cure for vasculitis however biological treatments often produce marvelous remission without necessity for chemotherapy side effects. Treatment is aimed at reducing pain and inflammation by prescribing non-steroidal anti-inflammatory drugs and corticosteroids. In severe cases cytotoxic drugs are given to kill the immune cells involved in inflammation. Rarely surgery is required to repair
This information is not meant as individualized medical advice. It is provided solely for education. Our practice would be pleased to discuss your unique circumstances and needs as they relate to these topics.